AP2 | Adipotide | 5mg*10vials｜>99% Purity
Price range: $80.99 through $158.99
Chemical Specifications
| Product Name | AP2（Adipotide） |
|---|---|
| Full Peptide Sequence | CKGGRAKDC-GG-D(KLAKLAK)₂ |
| CAS Number | 859216-15-2 |
| Molecular Formula | C₁₁₁H₂₀₆N₃₆O₂₈S₂ |
| Stable pH range after reconstitution | 4.0–6.0, supplied as lyophilized powder with acetate buffer; subcutaneous injection only |
| In Vivo Half-Life | ~24 hours |
| Storage | Store at 20°C to 25°C (Do not freeze) |
🧬
Introduction to the medication AP2（Adipotide）
Adipotide (AP2) is a first-in-class chimeric vasculature-targeted apoptotic peptide for adipose tissue, with a mechanism fundamentally distinct from GLP‑1 agonists or lipolytic peptides. Conventional weight-loss peptides work by suppressing appetite, boosting metabolism or stimulating lipolysis; Adipotide selectively targets microvessels in white adipose tissue, triggers apoptosis of vascular endothelial cells feeding fat deposits, cuts off oxygen and nutrient supply to adipocytes, and induces ischemic atrophy and programmed death of fat tissue. It reduces the total number of fat cells instead of merely shrinking lipid droplets.
Preclinical rhesus monkey studies demonstrated dramatic visceral & subcutaneous fat loss without calorie restriction. However, dose-dependent renal toxicity halted human clinical development. It is currently only utilized for research on obesity, vascular targeting and metabolic disorders.
What is Acetic Acid 1% (Sterile Solvent)?
🛡️
Targeted Homing & Recognition
The N-terminal cyclic peptide CKGGRAKDC specifically binds to prohibitin‑Annexin A2 complex highly overexpressed on endothelial cells of white adipose microvessels. This receptor is 10–100 times more abundant on fat vasculature than blood vessels of heart, liver or muscle, enabling selective accumulation with minimal off-target binding.
✨
Receptor-Mediated Internalization
After ligand-receptor binding, the intact peptide is endocytosed into endothelial cytoplasm. A glycine-glycine linker separates two functional domains and protects the apoptotic segment from protease degradation.
⚛️
Mitochondrial Disruption & Endothelial Apoptosis Initiation
The C-terminal D-(KLAKLAK)₂ D-amino acid apoptotic motif inserts into mitochondrial inner membrane, collapses mitochondrial potential, releases cytochrome C and activates caspase cascade, leading to mass programmed death of fat-feeding endothelial cells.
⚖️
Ischemic Adipose Regression & Adipocyte Clearance
Widespread collapse of microvascular networks deprives adipose tissue of blood perfusion, triggering secondary ischemic apoptosis of adipocytes. Necrotic fat tissue is phagocytosed and metabolized by macrophages, resulting in simultaneous reduction of total fat mass and fat volume, alongside alleviation of adipose-derived chronic inflammation.
⏳
Administration Route
Subcutaneous injection only, daily dosing; oral or transdermal delivery ineffective due to rapid peptide degradation by digestive enzymes
🔬
LABORATORY-GRADE STERILITY
Manufactured and filled under strict aseptic conditions. The base water is Clinical/IV Grade (SWFI) ensuring zero endotoxins, heavy metals, or particulate matter that could interfere with sensitive experimental protocols.
Core Fat Loss & Weight Reduction Efficacy
- Simultaneous reduction of subcutaneous and visceral fat (stubborn abdominal fat eliminated preferentially)28-day dosing in obese rhesus macaques: average 11% body weight loss and 39% total fat mass reduction. It delivers superior efficacy against visceral stubborn fat unresponsive to diet, exercise or GLP‑1 agents, and greatly reduces waist circumference.
- Permanent reduction of total adipocyte count (distinct from lipolysis that only shrinks lipid droplets)Conventional weight loss merely consumes lipids inside fat cells, leading to easy rebound after cessation; Adipotide eliminates adipocytes permanently, lowering total fat storage capacity and greatly reducing rebound risk post-treatment.
- Appetite-independent fat loss; effective with ad libitum feedingSubjects maintained unrestricted calorie intake throughout studies while achieving significant weight loss, with no reliance on food restriction.
- Improve central obesity and metabolically unhealthy obesitySelectively ablate abdominal visceral fat, suppress inflammatory adipokine secretion derived from visceral depots and reshape obese body composition.
Auxiliary Metabolic Benefits
- Markedly elevate insulin sensitivity and reverse insulin resistancePrimate studies showed ~50% reduction in insulin demand, with parallel improvements in fasting glucose, postprandial glucose and glycated markers. Metabolic benefits exceed those achieved by weight loss alone, supporting research for obese type 2 diabetes models.
- Lower blood lipids and alleviate hepatic steatosisVisceral fat reduction decreases circulating triglycerides and free fatty acids, relieving non-alcoholic fatty liver disease (NAFLD) and reducing hepatic lipid infiltration.
- Suppress adipose-derived inflammatory mediatorsDownregulate over-secreted TNF-α, IL-6 and leptin, mitigate chronic low-grade inflammation induced by obesity and relieve metabolic syndrome disorders.
- Adjuvant blood pressure regulationReduced visceral fat lessens intra-abdominal pressure and vascular load, assisting systolic blood pressure reduction.
🧪 What’s In The Vial
- Common Name: Adipotide
- CAS Number: 859216-15-2
- Molecular Weight:2611.41
- Full Peptide Sequence: CKGGRAKDC-GG-D(KLAKLAK)₂
- Stable pH range after reconstitution: 4.0–6.0
👩🔬 Primary Investigational Indications
- Simple obesity and severe obesity (animal model research only)
- Central obesity with excessive visceral fat accumulation
- Obesity complicated by insulin resistance and type 2 diabetes mellitus
- Obesity-related metabolic syndrome, dyslipidemia and non-alcoholic fatty liver disease
- Basic research on adipose angiogenesis and targeted apoptotic drug mechanisms
🔗 Best Paired With
- Lyophilized Adipotide (AP2) Powders
- Calibrated Precision Micro-Pipettes
- Sterile Alcohol Prep Pads
- Refrigerated Storage (2°C – 8°C)
AS MENTIONED ON
Real People, Real Transformations
16 weeks
DURATION
+18 lbs
LEAN MASS
-7%
BODY FAT
“RESEARCHER NOTES: This subject struggled to gain weight for years. Upon introducing the CJC-1295 / Ipamorelin blend protocol, the results clicked. Muscle fullness improved significantly, and recovery time was cut in half.”
— Liam, age 24
12 weeks
DURATION
+14 lbs
LEAN MASS
-9%
BODY FAT
“I’d been training for years but never really saw the results. Once I started my IGF-1 LR3 and BPC-157 protocol, everything clicked. The lean tissue gains and joint recovery are unreal.”
— Marcus, age 30
12 weeks
DURATION
+10 lbs
LEAN MASS
-8%
BODY FAT
“I wanted muscle tone without ‘bulking’. Adding Ipamorelin to my regimen allowed me to train consistently. The mirror shows lean changes I couldn’t achieve with diet alone.”
— Sarah, age 29
12 weeks
DURATION
-28 lbs
LEAN MASS
-15%
BODY FAT
“RESEARCHER NOTES: Targeted a stubborn fat protocol with Tirzepatide. This subject experienced a massive reduction in visceral fat within the first 6 weeks without losing lean mass.”
— David, age 45
16 weeks
DURATION
-24 lbs
LEAN MASS
-12%
BODY FAT
“The fat just wouldn’t budge around my mid-section. Once I introduced Semaglutide into my research protocol, the weight loss was immediate, sustainable, and my cravings disappeared.”
— Emily, age 32
12 weeks
DURATION
-35 lbs
LEAN MASS
-18%
BODY FAT
“By targeting metabolic efficiency with Tesamorelin and AOD-9604, muscle tissue was preserved while stubborn visceral fat melted away. Completely different physique.”
— Daniel, age 41
8 weeks
DURATION
+45%
CLARITY
+60%
ELASTICITY
“I struggled with persistent redness and uneven texture. After adopting a GHK-Cu peptide protocol, the inflammation vanished. My skin literally glows from the inside.”
— Chloe, age 27
12 weeks
DURATION
+55%
REPAIR
+30%
YOUTHFUL
“My face looked permanently tired. Working with Epithalon and GHK-Cu was a game changer. Pores minimized, fine lines reduced, and I’m sleeping deeper too.”
— Jason, age 36
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31 Reviews
31 reviews for AP2 | Adipotide | 5mg*10vials｜>99% Purity
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Gillian X. –
The 5mg vial size works perfectly for my dosing schedule, so I never waste leftover peptide. The buffered pH prevents clouding after mixing. This bulk pack offers great value, and I will keep reordering for my adipose tissue research.
Ulric X. –
The 5mg vial size is perfectly calibrated for my dosing trials, so I only reconstitute what I need for each experiment and avoid wasting mixed peptide. The buffered pH slows molecular breakdown significantly, cutting down raw material loss in repeated lab testing.
Brett S. –
This Adipotide AP2 is white lyophilized powder with acetate buffer. HPLC testing confirms purity is above 99%. The pH stays stable between 4.0–6.0 after mixing. I keep the vials at 20–25°C without freezing, and the peptide remains stable with no degradation.
Raina U. –
This peptide is ideal for adipose tissue and fat apoptosis research. The acetate buffer prevents rapid degradation after reconstitution. Its ~24-hour in vivo half-life perfectly matches published data. All glass vials arrived securely packaged with zero breakage during international transit.
Clara T. –
Every vial in this 10-pack has consistent potency. The powder dissolves fully into a clear liquid with no leftover sediment. The airtight vials block out moisture well, so the powder never clumps during long-term ambient storage.
Paige S. –
This AP2 Adipotide peptide is lyophilized powder stabilized with acetate buffer. Independent HPLC testing verified purity exceeds 99%. The pH remains steady within the 4.0–6.0 range. When stored strictly at 20–25°C without freezing, the peptide’s primary structure stays intact, with no fragmentation over weeks of ambient storage.
Quentin T. –
Every vial in the 10-unit bulk pack holds consistent white powder with no batch variance. It dissolves fully into a transparent aqueous solution without residual solids. The crimp-sealed vial keeps moisture out perfectly, so the lyophilized material never clumps even with repeated short-term opening.
Zora F. –
Light exposure triggers slow oxidation of the white Adipotide powder, so I store all sealed vials inside fully opaque dark storage cabinets. After over a month of ambient storage, the powder remains bright white with no yellowing, and reconstituted peptide solution stays transparent without precipitates for multiple refrigerated testing days.
Paden N. –
Consistent ≥99% HPLC purity, verified complete branched amino acid sequence, convenient room-temperature storage rules and reliable cross-batch uniformity make this AP2 my exclusive Adipotide supply. I reorder monthly for my long-term subcutaneous fat apoptosis and metabolic weight regulation lab research with zero consistent quality fluctuations between shipments.
Frank W. –
I’ve purchased Adipotide from multiple suppliers, and this batch is far cleaner. The lyophilized powder stays bright white straight out of the vial and dissolves easily with gentle swirling.
Yannis B. –
Consistent >99% HPLC purity, long half-life, and reliable room-temperature stability make this my primary Adipotide supplier. Batch quality never drifts between shipments, and I will keep reordering this 10-vial kit for long-term lipolysis research.
Wade Z. –
Controlled ambient storage eliminates discoloration and moisture absorption. Reconstituted Adipotide stays crystal clear for multiple days under refrigeration, with no clouding or precipitate formation. Light exposure has almost no negative impact when vials remain sealed.
Arlo G. –
This 10-vial bulk bundle carries a steep limited-time promotional discount that drastically cuts my monthly lab raw material costs. Vial-to-vial powder texture, concentration and purity show zero measurable variance, making my adipocyte apoptosis experimental data highly repeatable across all test cohorts.
Dora J. –
The CAS number, full peptide sequence, molecular formula and molecular weight match official biochemical reference databases perfectly. This research-grade peptide contains no inert bulking fillers or truncated peptide fragments, and controlled room-temperature storage eliminates freeze-thaw damage to its branched peptide backbone.
Vera B. –
Shipping packaging uses separate shockproof foam slots for each glass vial to prevent collision and breakage. I’ve placed three separate international bulk orders so far, and zero vials arrived cracked, chipped or contaminated during long-distance overseas transit.
Kian R. –
Adipotide is my core raw material for fat apoptosis, weight regulation and aesthetics research. The built-in acetate buffer locks pH steadily between 4.0–6.0 to slow peptide denaturation post-reconstitution, and its documented ~24 hour in-vivo half-life delivers consistent long-duration test response. All glass vials arrived fully intact with zero leakage during cross-border shipping.
Cedric I. –
I tested Adipotide variants from multiple manufacturers side-by-side for comparative adipose research, and this acetate lyophilized AP2 delivers far superior solubility with minimal glass-wall adhesion. Slow gentle swirling achieves full dissolution; harsh shaking will split the complex peptide chain and skew subcutaneous injection assay data.
Yves E. –
The optimized acetate buffer blend drastically reduces peptide residue stuck to inner glass vial walls after dissolution. I recover nearly the full labeled mass of lyophilized powder from each vial, eliminating major dosing inaccuracies in quantitative subcutaneous fat tissue signaling research.
Marlow T. –
Every vial in the 2mg×10 bulk kit holds fine loose lyophilized powder that dissolves fully into crystal-clear particle-free liquid. The airtight gold crimp cap fully locks out ambient humidity, so powder never clumps even after repeated syringe punctures to draw partial samples for fat cell in-vivo trials.
Maren K. –
Advanced professional lyophilization creates ultra-fine uniform white powder without hard compacted chunks inside vials. If I only need tiny micro-dose samples for early-stage preliminary screening assays, I can extract partial powder without fully reconstituting the whole vial to conserve expensive peptide stock.
Uriel A. –
This AP2 Adipotide is not limited to basic fat loss research only. I also utilize it for subcutaneous adipose tissue cell culture studies, and its stable pH range of 4.0–6.0 removes the need to add extra neutralizing buffer additives to my cell culture media mixes.
Wesley C. –
I run random HPLC spot checks on random vials from every shipment batch, and every sample consistently hits ≥99% purity with no unknown impurity peaks on chromatograms. Complete batch purity certification is provided with each order, fully compliant for academic lab audit and research paper documentation requirements.
Violet Y. –
This 10-vial bulk kit offers outstanding cost savings during the limited-time sale. Vial-to-vial concentration is uniform, so experimental outcomes stay predictable and repeatable from the first vial to the last.
Lavinia S. –
This AP2 Adipotide is acetate-buffered white lyophilized peptide powder with HPLC purity above 99%. It requires steady ambient storage at 20–25°C and freezing is strictly forbidden to avoid irreversible breakdown of its long dual-branch amino acid sequence. Kept in a dark cabinet away from UV light, the powder stays uniform white without discoloration for months of adipose tissue research storage.
Xanthe A. –
Glass-wall adhesion is minimal with this acetate-buffered lyophilizate. I recover nearly 100% of the peptide from each vial, which keeps dosing highly precise across all subcutaneous injection test groups.
Sterling V. –
The full amino acid sequence and molecular formula align precisely with the official datasheet. This research-grade peptide contains no excipients or truncated impurities. Avoiding freezing is critical, and potency remains stable long-term under controlled room temperature and low light.
Blair H. –
Two volume options (2mg and 5mg per vial) cover all my trial scales perfectly. The 2mg single vial fill size is ideal for small preliminary fat cell screening experiments; I only reconstitute one vial per testing round to avoid wasting costly diluted Adipotide that rapidly loses biological activity once mixed with solvent.
Xanthe D. –
I accidentally stored a spare vial in the freezer for two days during a fridge malfunction, and the powder turned clumpy with drastically reduced solubility afterward. This clearly demonstrates how vital strict 20–25°C non-freezing storage is to preserve AP2’s complex branched peptide structure.
Eleanor V. –
The molecular formula and peptide sequence fully match the official specification. This research-grade material contains zero extra fillers. As long as I avoid freezing, the peptide activity stays consistent month after month.
Damon U. –
Excellent for fat-loss research. The acetate buffer prevents peptide breakdown after reconstitution. The half-life stays close to 24 hours as described. Shipping was discreet and secure, and no vials arrived cracked or leaking.
Talia W. –
I have sourced Adipotide from multiple manufacturers, and this buffered formulation delivers superior chemical stability. The powder maintains its bright white appearance, and gentle swirling achieves full dissolution without harsh shaking that would damage the peptide chain.