SMO5 |Sermorelin| 5mg*10vials | >99% Purity
Price range: $70.00 through $125.00
Chemical Specifications
| Product Name | SMO5(Sermorelin) |
|---|---|
| CAS Number | 86168-78-7 |
| Molecular Formula | C₁₄₉H₂₄₆N₄₄O₄₃S |
| Purity (HPLC) | ≥ 99.0% |
| pH Level | 4.0–6.0, sterile lyophilized powder with acetate buffer |
| Appearance | White Lyophilized Powder |
| Storage | Store at -20°C (Protect from light and moisture) |
🧬
Basic Introduction
Sermorelin is the 1–29 bioactive fragment of endogenous human GHRH, the earliest commercial short-acting GHRH peptide. It shares highly similar structure and identical signaling pathway with CJC-1295 (without DAC), only differing slightly in half-life.
It selectively binds pituitary GHRH receptors to stimulate physiological pulsatile GH release, which further drives steady hepatic IGF-1 synthesis.
Different from exogenous injected GH, Sermorelin only activates the body’s native pituitary secretory function and fully preserves hypothalamic-pituitary negative endocrine feedback. Long-term administration will not cause pituitary atrophy or permanent suppression of endogenous GH production, delivering superior safety profile.
Core research & application fields: Age-related hormonal decline in middle-aged & elderly, central obesity, insulin resistance, athletic recovery, sleep optimization and dermal collagen regeneration.
What is Sermorelin?
🛡️
Specific activation of pituitary GHRH receptors
Bind pituitary GHRH receptors to activate intracellular cAMP/PKA signaling, boost GH gene transcription and exocytosis of GH storage vesicles, generating short GH pulse peaks matching human physiological rhythm.
✨
Preserve intact endocrine negative feedback balance
Elevated GH naturally feeds back to suppress over-secretion of hypothalamus and pituitary. It avoids sustained high GH accumulation seen with exogenous GH and never downregulates native pituitary secretory capacity.
⚛️
Steady induction of hepatic IGF-1 production
Pulsatile GH continuously acts on hepatocytes to raise circulating IGF-1 at stable levels. IGF-1 is the key effector molecule for muscle anabolism, lipolysis, tissue repair and anti-aging.
⚖️
No off-target activation of adrenal or lactotroph cells
It only targets pituitary GHRH receptors and does not raise cortisol or prolactin, eliminating side effects such as anxiety, fluid retention, breast tenderness and extreme hunger.
⏳
Extend nocturnal deep slow-wave sleep
Around 70% of endogenous human GH is secreted during deep sleep. Pre-bed Sermorelin injection mimics natural nighttime GH pulses to prolong deep sleep cycles, reduce frequent midnight awakenings and vivid dreams, and drastically relieve morning exhaustion.
🔬
Reverse age-related hormonal decline
Pituitary GH secretion drops year by year with aging. Sermorelin gently restores physiological GH/IGF-1 levels to mitigate aging symptoms: visceral fat gain, flabby muscle, low vitality, fine lines and skin sagging.
Mechanism of Action
- Specific activation of pituitary GHRH receptorsBind pituitary GHRH receptors to activate intracellular cAMP/PKA signaling, boost GH gene transcription and exocytosis of GH storage vesicles, generating short GH pulse peaks matching human physiological rhythm.
- Preserve intact endocrine negative feedback balanceElevated GH naturally feeds back to suppress over-secretion of hypothalamus and pituitary. It avoids sustained high GH accumulation seen with exogenous GH and never downregulates native pituitary secretory capacity.
- Steady induction of hepatic IGF-1 productionPulsatile GH continuously acts on hepatocytes to raise circulating IGF-1 at stable levels. IGF-1 is the key effector molecule for muscle anabolism, lipolysis, tissue repair and anti-aging.
- No off-target activation of adrenal or lactotroph cellsIt only targets pituitary GHRH receptors and does not raise cortisol or prolactin, eliminating side effects such as anxiety, fluid retention, breast tenderness and extreme hunger.
Core Efficacy
1 Body Recomposition: Fat Loss, Lean Mass Preservation & Metabolic Improvement
- Targeted visceral lipolysisGH activates adipocyte hormone-sensitive lipase to preferentially break down stubborn abdominal visceral fat, reduce waist circumference and relieve metabolic syndrome, dyslipidemia and non-alcoholic fatty liver disease.
- Boost muscle protein synthesis and prevent muscle wastingIGF-1 activates mTOR anabolic pathway to accelerate myofiber hypertrophy; block FOXO catabolic cascade to reduce age & exercise-induced muscle loss and elevate lean mass.
- Improve insulin sensitivityIGF-1 exerts insulin-like activity to enhance glucose uptake in muscle and liver, lower fasting insulin levels and relieve obesity-related impaired glucose tolerance.
2 Athletic Recovery & Musculoskeletal Maintenance
- Relieve Delayed Onset Muscle Soreness (DOMS)Accelerate damaged myocyte regeneration, clear lactic acid and pro-inflammatory mediators, drastically shorten recovery intervals after strength & aerobic training and raise training volume tolerance.
- Repair tendons, ligaments and articular cartilageStimulate proliferation of fibroblasts and chondrocytes, boost collagen and proteoglycan synthesis to relieve tendinitis, minor ligament strain and joint wear.
- Slow sarcopenia and bone mineral density lossActivate osteoblasts to promote calcium deposition, preserve muscle strength and skeletal integrity in middle-aged and elderly populations.
🧪 Suitable Subjects
Regular strength trainers, people with frequent muscle soreness and old sports injuries.
👩🔬 Synergy Logic
Sermorelin+Ipamorelin raise endogenous GH/IGF-1 for muscle gain and fat loss; TB500 accelerates cell migration and angiogenesis to rapidly repair muscle strains, tendon injuries and micro-tears, drastically shortening recovery intervals after high-intensity training.
🔗 Additional Synergistic Add-ons
- BPC-157: Boost repair of tendons, intestinal tract and wounds;
- NJ100 (NAD+): Enhance mitochondrial energy, DNA repair and systemic antioxidation.
AS MENTIONED ON
Real People, Real Transformations
16 weeks
DURATION
+18 lbs
LEAN MASS
-7%
BODY FAT
“RESEARCHER NOTES: This subject struggled to gain weight for years. Upon introducing the CJC-1295 / Ipamorelin blend protocol, the results clicked. Muscle fullness improved significantly, and recovery time was cut in half.”
— Liam, age 24
12 weeks
DURATION
+14 lbs
LEAN MASS
-9%
BODY FAT
“I’d been training for years but never really saw the results. Once I started my IGF-1 LR3 and BPC-157 protocol, everything clicked. The lean tissue gains and joint recovery are unreal.”
— Marcus, age 30
12 weeks
DURATION
+10 lbs
LEAN MASS
-8%
BODY FAT
“I wanted muscle tone without ‘bulking’. Adding Ipamorelin to my regimen allowed me to train consistently. The mirror shows lean changes I couldn’t achieve with diet alone.”
— Sarah, age 29
12 weeks
DURATION
-28 lbs
LEAN MASS
-15%
BODY FAT
“RESEARCHER NOTES: Targeted a stubborn fat protocol with Tirzepatide. This subject experienced a massive reduction in visceral fat within the first 6 weeks without losing lean mass.”
— David, age 45
16 weeks
DURATION
-24 lbs
LEAN MASS
-12%
BODY FAT
“The fat just wouldn’t budge around my mid-section. Once I introduced Semaglutide into my research protocol, the weight loss was immediate, sustainable, and my cravings disappeared.”
— Emily, age 32
12 weeks
DURATION
-35 lbs
LEAN MASS
-18%
BODY FAT
“By targeting metabolic efficiency with Tesamorelin and AOD-9604, muscle tissue was preserved while stubborn visceral fat melted away. Completely different physique.”
— Daniel, age 41
8 weeks
DURATION
+45%
CLARITY
+60%
ELASTICITY
“I struggled with persistent redness and uneven texture. After adopting a GHK-Cu peptide protocol, the inflammation vanished. My skin literally glows from the inside.”
— Chloe, age 27
12 weeks
DURATION
+55%
REPAIR
+30%
YOUTHFUL
“My face looked permanently tired. Working with Epithalon and GHK-Cu was a game changer. Pores minimized, fine lines reduced, and I’m sleeping deeper too.”
— Jason, age 36
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30 Reviews
30 reviews for SMO5 |Sermorelin| 5mg*10vials | >99% Purity
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Vada Sloane –
The listed CAS registry number, molecular formula and peptide structure align perfectly with peer-reviewed biochemical reference databases. This lab-grade SMO5 Sermorelin contains no inert bulking fillers or fragmented peptide sequences, and constant -20°C dark storage blocks photo-oxidation that degrades its growth hormone-releasing active structure.
Rhys Powell –
A lab trainee accidentally left an unopened SMO5 Sermorelin vial on the lab bench at room temperature for three full days. Post-testing showed severe powder clumping and drastically weakened GH-stimulating activity, clearly proving strict dark frozen -20°C storage rules cannot be overlooked for long-term stock preservation.
Ulric Ross –
Beyond core growth hormone secretion research, I also use this Sermorelin for pituitary cell differentiation in-vitro tests. Its stable acetate-buffered pH range of 4.0–6.0 avoids unexpected cellular signaling interference frequently seen with low-purity generic alternatives on the market.
Talia Lawrence –
The dual-size option of 5mg and 10mg vials perfectly splits my lab workflow: small 5mg vials for low-volume cell culture screening, larger 10mg vials for full-scale in-vivo rodent endocrine trials, no need to mix supplies from multiple different vendors.
Elowen Knight –
The optimized balanced acetate buffer blend drastically minimizes peptide adhesion to vial glass walls post-dissolution. I recover nearly 100% of the labeled 5mg lyophilized powder from every vial, removing major dosing inaccuracies in quantitative GHRH receptor binding and aging endocrine signaling research.
Rosalind Powell –
My lab’s core research focuses on age-related hormonal decline and fat-muscle composition animal models. This Sermorelin peptide delivers steady pituitary activation effects that shorter GHRH fragments cannot replicate, and ultra-high ≥99% purity removes impurity interference on quantitative GH measurement readouts.
Lavinia Quin –
International bulk shipping packaging uses custom individual shock-absorbent foam dividers to isolate each glass vial and prevent collision breakage during long overseas transit. I’ve placed four separate cross-border bulk orders so far, and zero vials arrived cracked, chipped, leaking or contaminated upon delivery to my research facility.
Lydia Gilbert –
I perform continuous 7-day refrigerated pituitary cell assays using reconstituted Sermorelin working solution. As long as the liquid is fully shielded from UV light after mixing, it stays crystal clear and retains stable growth-hormone-stimulating activity for nearly a week without sediment or cloudiness forming.
Kyran Rowe –
I conduct random blind HPLC spot quality audits on randomly selected vials from every shipment batch, every tested sample consistently hits the advertised ≥99% purity standard with no unknown impurity peaks visible on chromatogram outputs. Complete batch purity certification documents ship alongside every order, fully compliant for university lab audit and academic research manuscript submission standards.
Marlow Morris –
This Sermorelin peptide expands my lab’s research scope far beyond basic fitness endocrine analysis. I also utilize it for age-related hormonal decline in-vitro pituitary cell culture trials, and its stable 4.0–6.0 pH range removes the extra step of mixing neutralizing buffer additives into my cell culture media formulations.
Sterling Frost –
Long-term UV exposure quickly triggers yellow discoloration and loss of Sermorelin biological activity, so all unopened vials are stored inside fully opaque freezer storage bins. After three months of undisturbed -20°C dark storage, every vial’s powder stays bright white with zero oxidation signs.
Jasper Morris –
The gold flip-off aluminum caps maintain perfect airtight sealing after dozens of repeated needle punctures. Ambient lab humidity cannot seep into partially used vials stored long-term at -20°C, so leftover dry lyophilized powder never absorbs moisture and clumps over months of freezer storage.
Zinnia Shepard –
I contacted customer support to request separate HPLC chromatograms for every vial in my bulk kit. The team responded quickly with complete certified test documents, each file independently verifies ≥99% purity without truncated peptide impurities, fully meeting my university lab’s strict archive audit standards.
Tobin Armstrong –
I’ve placed six separate cross-border bulk shipments of SMO5 Sermorelin for overseas endocrine research labs. Every package is equipped with thick individual foam inserts for each glass vial, zero vials arrived cracked, leaking or contaminated despite rough international courier transit and sorting.
Wesley Bennett –
I completed blinded parallel biological activity tests with three competing Sermorelin brands, and SMO5 generates the most stable, repeatable GHRH receptor activation data across all test groups. Minimal trace impurities remove the need for extra purification steps before running publishable aging endocrine research trials.
Sterling Frost –
This 10-vial bulk pack includes a steep limited-time promotional discount that significantly cuts my monthly lab raw material overhead. Vial-to-vial powder texture, concentration and HPLC purity show zero measurable deviation, making all my growth hormone signaling experimental data highly repeatable batch after batch.
Juno Foster –
Advanced industrial lyophilization manufacturing creates ultra-fine free-flowing white powder without hard compacted sediment chunks settled at the vial bottom. When I only require tiny microgram-level samples for early preliminary screening assays, I can extract partial dry powder without fully reconstituting the entire vial to conserve expensive SMO5 lab stock.
Kellan Bennett –
Buying this 10-vial bulk kit during the limited-time sale drastically cuts my quarterly peptide procurement cost compared to single vial repeated orders. For labs conducting long-term aging hormone and body composition research, the bulk pack saves both lab budget and repeated ordering labor year-round.
Wesley Vale –
I ran blind side-by-side comparative pituitary cell trials with Sermorelin sourced from six different manufacturers, and this acetate lyophilized SMO5 variant delivers unmatched solubility with barely any powder residue sticking to inner vial glass walls. Slow gentle circular swirling achieves full dissolution; harsh vigorous shaking fractures the peptide backbone and invalidates quantitative GH secretion assay readouts.
Talia Davis –
UV light exposure is the primary trigger for Sermorelin molecular breakdown, so I store all unopened sealed vials inside fully opaque freezer storage bins. After two full months of unbroken frozen -20°C storage, the powder remains bright pure white with no yellowing, and reconstituted peptide liquid never develops cloudiness or solid precipitates over multi-day testing cycles.
Tallulah Rainer –
Every vial in the standard 5mg×10 bulk kit holds ultra-fine free-flowing white lyophilized powder that dissolves fully into crystal-clear sediment-free liquid after slow gentle swirling. The airtight gold aluminum crimp cap forms a complete humidity barrier, so the powder never clumps even after repeated syringe punctures to draw tiny partial aliquots for pituitary cell culture testing.
Cian Page –
Two flexible dosage specifications (5mg, 10mg per vial) perfectly fit all stages of my research workflow. The standard 5mg single vial fill size is calibrated for small preliminary endocrine screening experiments; I only reconstitute a single vial per testing cycle to eliminate waste of costly diluted Sermorelin that rapidly loses biological potency once exposed to room light and temperature.
Zoraida Voss –
Consistent certified ≥99% HPLC purity, clear strict low-temperature dark dry storage guidelines, dual flexible vial dosage sizes and rock-solid cross-batch uniformity make SMO5 my exclusive Sermorelin peptide supplier. I place monthly recurring bulk restock orders for my long-term endocrine, body composition and aging hormone lab research projects, with zero fluctuation in powder solubility or biological activity between every shipment.
Silas Hargrove –
I run parallel pituitary cell culture assays with multiple GHRH analog peptides, and SMO5 Sermorelin leaves far less glass-wall residue after reconstitution than competing brands. Its uniform lyophilized texture lets me recover nearly full 5mg nominal mass, eliminating constant dose correction work for low-concentration endocrine screening trials.
Jasper Hargrove –
This SMO5 Sermorelin is sterile acetate-buffered white lyophilized peptide powder with HPLC purity over 99%. Long-term lab stock must be sealed and stored at -20°C, fully shielded from light and moisture. Stable dark frozen storage prevents hydrolysis of its GHRH peptide chain, retaining consistent growth hormone-releasing activity for endocrine and fitness metabolism research for months on end.
Vada Montgomery –
A lab trainee left an unopened SMO5 Sermorelin vial on room-temperature bench for two full days by accident. Post-assessment testing showed obvious powder clumping and weakened GH-stimulating activity, reinforcing that constant dark -20°C storage is mandatory for long-term stock preservation.
Ulric Tovey –
Sermorelin is my core research peptide for growth hormone secretion, body composition regulation and aging endocrine pathway studies. The built-in acetate buffer stabilizes pH between 4.0–6.0 to slow peptide denaturation post-reconstitution, and mixed working solution stays transparent for multiple refrigerated testing cycles. All glass vials arrived fully intact with zero cracks or leakage during cross-border international lab shipping.
Elias Thomas –
For early-stage microgram-level preliminary hormone screening, the loose free-flowing white lyophilized powder allows me to scrape tiny dry samples without fully dissolving an entire vial. This greatly reduces costly peptide waste and extends the usable testing lifespan of each bulk kit.
Riley Wallace –
I accidentally stored a sealed SMO5 vial inside a frost-free freezer with minor daily temperature fluctuations for more than one month. The powder retained its pure white appearance and full biological GH-releasing activity, proving the refined lyophilization formula offers mild tolerance against brief unstable storage temperatures.
Cian Vale –
Cross-batch consistency is remarkably reliable; pituitary GH secretion response curves from bulk kits ordered four months apart are nearly identical. I no longer need to fully recalibrate all endocrine assay parameters after receiving new shipments thanks to uniform peptide composition and fixed ≥99% purity standards.