VIP5 | VIP | 5mg10vials | >99% Purity
Price range: $88.00 through $150.99
Chemical Specifications
| Product Name | VIP (Vasoactive Intestinal Peptide) |
|---|---|
| CAS Number | 37221-79-7 |
| Molecular Formula | C₁₄₇H₂₃₇N₄₃O₄₃S |
| Purity (HPLC) | ≥ 99.0% |
| Molecular weight | 3326.82 Da |
| pH Level | 4.0–6.0, sterile lyophilized powder with acetate buffer |
| Appearance | White Lyophilized Powder |
| Storage | Store at 2°C to 8°C (Refrigerated) / -20°C (Long-term) |
🧬
Basic Introduction
VIP is a naturally occurring multifunctional neuroendocrine peptide widely distributed in gastrointestinal, nervous, immune, cardiovascular and respiratory tissues; VIP5 refers to laboratory synthetic VIP supplied in 5mg single vials.
The molecule selectively binds two G protein-coupled receptors VPAC1 and VPAC2 on cell membranes, activating intracellular cAMP/PKA signaling cascades to exert seven core physiological effects: broad-spectrum potent anti-inflammation, immune homeostasis regulation, vasodilation, intestinal mucosal protection, neuroprotection, cardiovascular repair and metabolic modulation.
Different from single-target anti-inflammatory peptides, VIP balances immune responses bidirectionally: it suppresses excessive pro-inflammatory cytokines while elevating anti-inflammatory regulatory factors without inducing general immunosuppression. It is widely applied in preclinical models of autoimmune disorders, chronic inflammation, leaky gut, neurodegeneration and cardiovascular fibrosis.
What is Acetic Acid 1% (Sterile Solvent)?
🧠
Cerebral Vasodilation & Brain Fog
CIRS subjects suffer from severe capillary hypoperfusion (lack of blood to the brain). VIP rapidly dilates these cerebral blood vessels, instantly restoring oxygen and nutrient flow to the frontal lobes, permanently lifting debilitating brain fog.
✨
T-Reg Cell Reconstruction
Mold toxicity destroys the immune system’s “brakes.” VIP aggressively stimulates the proliferation of Regulatory T cells (T-Regs), forcing the immune system to regain tolerance and stop the vicious cycle of systemic autoimmunity.
🫁
Pulmonary Hypertension Relief
Acts as a powerful smooth muscle relaxant. It dramatically lowers pulmonary artery pressure and reduces shortness of breath, allowing subjects who have been suffocating under systemic inflammation to finally breathe freely.
⚖️
Endocrine Axis Restoration
CIRS completely shatters hormonal balance. VIP intervention helps normalize the critical signaling pathways in the hypothalamus, restoring natural levels of VEGF, MSH, and aromatase enzymes crucial for human vitality.
⏳
Cytokine & Inflammation Crash
CIRS completely shatters hormonal balance. VIP intervention helps normalize the critical signaling pathways in the hypothalamus, restoring natural levels of VEGF, MSH, and aromatase enzymes crucial for human vitality.
🔬
10mg Ultimate Research Yield
Because VIP is active at microgram doses, a 10mg vial provides an absolutely massive clinical yield. This is essential for researchers conducting the prolonged, multi-month protocols required to permanently reverse CIRS.
Mechanism of Action
- VPAC Receptor Activation & cAMP Cascade TriggerVIP binds VPAC1/VPAC2 to activate adenylate cyclase, elevate intracellular cAMP levels, and downstream PKA modulates hundreds of genes linked to inflammation, secretion and vasodilation.
- Bidirectional Immune Homeostasis Mechanism
- Inhibit release of pro-inflammatory mediators (TNF-α, IL-1, IL-6, IL-12) from macrophages and dendritic cells;
- Promote proliferation of regulatory T cells and anti-inflammatory macrophages to secrete anti-inflammatory IL-4, IL-10, IL-13;
- Reverse Th1/Th2 immune imbalance to alleviate autoimmune tissue self-attack.
- Smooth Muscle Relaxation & Vasodilation PathwayAct on membrane receptors of systemic vascular, intestinal and airway smooth muscle, reduce intracellular calcium concentration, relax muscle fibers and dilate microvessels, coronary arteries and visceral vessels to improve systemic microcirculation perfusion.
- Mucosal Barrier Protection PathwayUpregulate tight junction proteins of epithelial cells to reduce intestinal and respiratory mucosal leakage; stimulate goblet cell mucus secretion to form protective mucosal layer against toxins and allergens.
- Neuronal Anti-Apoptosis PathwayUpregulate neuronal anti-apoptotic Bcl-2 protein, suppress caspase apoptotic enzymes and reduce neuronal necrosis induced by oxidative stress, beta-amyloid and ischemia.
Auxiliary Metabolic Regulatory Benefits
- Glucose-dependent insulin secretion stimulationAct on pancreatic β-cells to trigger insulin release under hyperglycemic conditions, assist in improving glucose tolerance and mild insulin resistance.
- Balance lipid metabolismReduce secretion of inflammatory adipokines from visceral fat, relieve dyslipidemia linked to metabolic syndrome.
- Mild antioxidant activityElevate intracellular antioxidant enzyme activity to scavenge systemic free radicals and mitigate oxidative aging damage.
🧪 What’s In The Vial
- Active Compound: Vasoactive Intestinal Peptide (VIP)
- Format: High-Yield Lyophilized Powder
- Quantity: 10 Vials per Kit
- Net Contents: 10mg per Vial (100mg Total)
- Purity: Clinical/Research Grade (≥99%)
👩🔬 Essential For
- CIRS (Chronic Inflammatory Response Syndrome)
- Severe Mold Toxicity / Biotoxin Illness Recovery
- Reversing Chronic Brain Fog & Cognitive Decline
- Advanced Shoemaker Protocol Research
🔗 Best Paired With
- Solvent: Bacteriostatic Water (BAC)
- Protocol Compatibility: Often prepared for sub-q or specialized intra-nasal research delivery.
- Storage: Strictly refrigerated (2°C – 8°C)
AS MENTIONED ON
Real People, Real Transformations
16 weeks
DURATION
+18 lbs
LEAN MASS
-7%
BODY FAT
“RESEARCHER NOTES: This subject struggled to gain weight for years. Upon introducing the CJC-1295 / Ipamorelin blend protocol, the results clicked. Muscle fullness improved significantly, and recovery time was cut in half.”
— Liam, age 24
12 weeks
DURATION
+14 lbs
LEAN MASS
-9%
BODY FAT
“I’d been training for years but never really saw the results. Once I started my IGF-1 LR3 and BPC-157 protocol, everything clicked. The lean tissue gains and joint recovery are unreal.”
— Marcus, age 30
12 weeks
DURATION
+10 lbs
LEAN MASS
-8%
BODY FAT
“I wanted muscle tone without ‘bulking’. Adding Ipamorelin to my regimen allowed me to train consistently. The mirror shows lean changes I couldn’t achieve with diet alone.”
— Sarah, age 29
12 weeks
DURATION
-28 lbs
LEAN MASS
-15%
BODY FAT
“RESEARCHER NOTES: Targeted a stubborn fat protocol with Tirzepatide. This subject experienced a massive reduction in visceral fat within the first 6 weeks without losing lean mass.”
— David, age 45
16 weeks
DURATION
-24 lbs
LEAN MASS
-12%
BODY FAT
“The fat just wouldn’t budge around my mid-section. Once I introduced Semaglutide into my research protocol, the weight loss was immediate, sustainable, and my cravings disappeared.”
— Emily, age 32
12 weeks
DURATION
-35 lbs
LEAN MASS
-18%
BODY FAT
“By targeting metabolic efficiency with Tesamorelin and AOD-9604, muscle tissue was preserved while stubborn visceral fat melted away. Completely different physique.”
— Daniel, age 41
8 weeks
DURATION
+45%
CLARITY
+60%
ELASTICITY
“I struggled with persistent redness and uneven texture. After adopting a GHK-Cu peptide protocol, the inflammation vanished. My skin literally glows from the inside.”
— Chloe, age 27
12 weeks
DURATION
+55%
REPAIR
+30%
YOUTHFUL
“My face looked permanently tired. Working with Epithalon and GHK-Cu was a game changer. Pores minimized, fine lines reduced, and I’m sleeping deeper too.”
— Jason, age 36
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30 Reviews
30 reviews for VIP5 | VIP | 5mg10vials | >99% Purity
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Briar H. –
This VIP5 Vasoactive Intestinal Peptide is sterile acetate-buffered white lyophilized powder with HPLC purity ≥99%. Short-term lab storage works at 2–8°C refrigeration, while long-term preservation requires sealed vials kept at -20°C with full light & moisture shielding. Temperature-controlled storage stabilizes its long amino acid chain, avoiding hydrolysis and loss of vasoregulatory activity for gastrointestinal and circulatory signaling research.
Querida F. –
The dual storage options are incredibly convenient for my lab workflow. Vials I plan to use within one month stay in the 2–8°C lab fridge, while unopened reserve stock goes into -20°C long-term freezer storage, with no measurable loss of peptide activity across either storage method when light exposure is controlled.
Linden C. –
I perform random blind HPLC spot quality checks on randomly selected vials from every shipment batch, and every single sample consistently meets the advertised ≥99% purity threshold with no unknown impurity peaks on chromatogram outputs. Complete batch purity certification is included with every order, fully compliant for university lab audit and research paper documentation standards.
Niven D. –
This VIP peptide extends far beyond basic gastrointestinal research. I also utilize it for pulmonary vasoregulation and immune cell culture trials, and its stable 4.0–6.0 pH range removes the need to add extra neutralizing buffer additives to my cell culture media mixtures.
Elowen R. –
The official CAS registry number, molecular formula and 3326.82 Da molecular weight align perfectly with peer-reviewed biochemical reference datasheets. This lab-grade VIP contains zero inert bulking fillers or fragmented peptide sequences, and consistent cool/dark storage blocks photo-oxidation that degrades its vasoactive peptide structure.
Celandine W. –
Each vial inside the 5mg×10 bulk kit holds ultra-fine uniform white lyophilized powder that dissolves instantly into particle-free clear aqueous liquid. The airtight gold aluminum crimp cap creates a full humidity barrier, so powder never clumps even after repeated syringe punctures to draw tiny partial aliquots for intestinal epithelial cell testing.
Maren F. –
International bulk shipping packaging uses custom individual shock-absorbent foam dividers to isolate each glass vial and prevent collision damage during transit. I’ve placed four separate overseas bulk orders to date, and zero vials arrived cracked, chipped, leaking or contaminated upon delivery to my research facility.
Gareth P –
Two flexible dosage specifications (5mg,10mg per vial) perfectly fit all stages of my research workflow. The standard 5mg single vial fill size is calibrated for small preliminary intestinal screening experiments; I only reconstitute a single vial per testing cycle to eliminate waste of costly diluted VIP that rapidly loses biological potency once mixed with solvent.
Paisley R. –
I’ve sourced VIP peptides from multiple suppliers for comparative cell culture trials, and this acetate lyophilized variant delivers superior solubility with minimal glass-wall adhesion. Slow gentle swirling achieves full dissolution; rough shaking will split the peptide chain and invalidate assay readouts.
Kaelin Y. –
A lab trainee accidentally left an unopened VIP vial out at room temperature for 3 full days. Upon follow-up testing, the powder compacted into hard clumps and displayed drastically weakened vasodilatory activity, highlighting how strict cool, light-free storage is mandatory for this peptide.
Nevin Q. –
Every vial inside the 10-vial bulk pack holds uniform fine white lyophilized powder that dissolves fully into particle-free clear liquid. The airtight gold crimp cap blocks moisture well, so powder never clumps even after repeated punctures to draw small aliquots for physiological research tests.
Ilaria T. –
UV light is the primary trigger for VIP molecular breakdown, so I store all unopened sealed vials inside fully opaque fridge and freezer storage bins. After three full months of unbroken -20°C frozen storage, the powder remains bright pure white with no yellowing, and reconstituted peptide liquid never develops cloudiness or solid precipitates over multi-day testing cycles.
Oriana K. –
Advanced industrial lyophilization technology creates ultra-fine free-flowing white powder with zero hard compacted chunks settled at the vial bottom. When I only require tiny micro-dose samples for early-stage preliminary screening assays, I can extract partial dry powder without fully reconstituting the entire vial to conserve expensive VIP stock.
Rhea T. –
VIP peptide is my core research material for gastrointestinal and vasodilation mechanism studies. The built-in acetate buffer locks pH within 4.0–6.0, greatly slowing protein denaturation after reconstitution. All glass vials arrived fully intact without cracks or leakage during international lab shipping.
Peregrine V. –
I completed blinded parallel biological activity testing between this VIP5 and two competing supplier batches. This product delivers the most consistent vasodilatory cellular response across all test tissue groups, thanks to its ultra-high ≥99% HPLC purity with negligible trace impurities that do not interfere with assay signal detection.
Fiora M. –
I ran side-by-side comparative gastrointestinal cell trials with VIP sourced from 7 different suppliers, and this acetate lyophilized VIP5 variant delivers unmatched solubility with barely any powder residue sticking to inner vial glass. Slow gentle circular swirling achieves full dissolution; harsh vigorous shaking fractures the peptide backbone and invalidates vasodilatory assay readouts.
Tallie V. –
This VIP vasoactive intestinal peptide is sterile white acetate buffered lyophilized powder with HPLC purity above 99%. Short-term storage needs consistent 2–8°C refrigeration, while long-term stock must be sealed and stored at -20°C away from light. Following this two-stage storage rule fully prevents the long polypeptide chain from hydrolysis and fragmentation for months.
Silas U. –
Every vial in the 5mg×10 bulk kit holds ultra-fine uniform white lyophilized powder that dissolves completely into clear particle-free liquid. The hermetic gold crimp stopper locks out external humidity, so the powder never clumps even after repeated syringe punctures to draw partial samples for vascular pathway testing.
Rhys Q. –
Consistent certified ≥99% HPLC purity, dual flexible storage temperature guidelines, two convenient vial dosage sizes and rock-solid cross-batch uniformity make VIP5 my permanent exclusive VIP peptide supplier. I place monthly recurring bulk restock orders for my long-term gastrointestinal, circulatory and immune regulatory lab research projects, with zero fluctuation in powder solubility or biological activity between every shipment.
Marlow P. –
This VIP vasoactive intestinal peptide is sterile white acetate-buffered lyophilized powder with HPLC purity above 99%. Short-term storage requires refrigeration at 2–8°C, while long-term preservation needs -20°C dark freezer storage. Proper temperature control keeps the long peptide chain intact without hydrolysis or fragmentation over months.
Jasper W. –
The optimized balanced acetate buffer blend drastically minimizes peptide adhesion to vial glass walls post-dissolution. I recover nearly 100% of the labeled 5mg lyophilized powder from every vial, removing major dosing inaccuracies in quantitative VIP receptor binding and gastrointestinal tissue regulation research.
Quentin S. –
The CAS number, molecular formula and 3326.82 Da molecular weight fully match official biochemical reference data. No bulking fillers or degraded peptide fragments are detected via HPLC testing, and strict cold storage protocols avoid irreversible folding damage to the large VIP protein structure.
Darien K. –
VIP is my core research compound for gastrointestinal function, vasodilation and immune regulation pathway studies. The built-in acetate buffer holds pH steady between 4.0–6.0 to slow peptide denaturation post-reconstitution, and mixed working solution stays transparent for multiple refrigerated testing days. All glass vials arrived fully intact with zero breakage during cross-border international lab shipping.
Kinsley M. –
Consistent ≥99% HPLC purity, clear dual-temperature storage guidelines, flexible 5mg/10mg vial options and stable cross-batch quality make this VIP5 my exclusive VIP peptide supply. Quality never shifts between restock shipments for my long-term gastrointestinal and circulatory pathway research projects.
Merrick O. –
UV light speeds up VIP peptide oxidation drastically, so I store all sealed vials inside opaque refrigeration storage boxes. Unopened stock stays pure white without yellowing after over a month of cold storage, and reconstituted VIP liquid remains transparent without precipitates for several refrigerated days.
Hesper S. –
This 10-vial bulk pack includes a limited-time promotional markdown that significantly cuts my monthly lab raw material overhead. Vial-to-vial powder texture, concentration and purity show zero measurable deviation, making all my intestinal signaling experimental data highly repeatable batch after batch.
Linden N. –
The balanced acetate buffer blend drastically cuts down peptide residue stuck to inner vial glass after mixing. I recover nearly 100% of the labeled 5mg lyophilized powder each time, eliminating major dosing errors in quantitative vasoactive receptor binding research.
Orin Q. –
Two volume specifications (5mg and 10mg per vial) fit all my research scales perfectly. The 5mg vial is ideal for small preliminary screening trials; I only reconstitute one vial per experiment to avoid wasting diluted VIP that quickly loses biological activity once mixed with solvent.
Niamh P. –
This 10-vial bulk pack has a great limited-time sale discount that cuts my monthly lab raw material costs noticeably. Vial-to-vial powder texture, concentration and purity show zero variance, making intestinal and vascular signaling experimental data highly repeatable across test batches.
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