IG1| IGF-1LR3｜1mg*10vials| 0.1mg-1mg|>99% Purity
Price range: $38.00 through $175.00
Chemical Specifications
| Product Name | IGF-1 LR3 |
|---|---|
| CAS Number | 946870-92-4 |
| Molecular Formula | C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉ |
| Molecular weight | 9117.50 Da |
| Purity (HPLC) | ≥ 99.0% |
| pH Level | 4.0–6.0, lyophilized powder with acetate buffer |
| Appearance | White Lyophilized Powder |
| Storage | Store at 20°C to 25°C (Do not freeze) |
🧬
Basic Introduction
IGF-1 LR3 is a synthetic long-acting analog of insulin-like growth factor 1, the primary downstream effector molecule of growth hormone (GH). Native human IGF-1 is secreted by the liver under GH stimulation, yet over 98% is sequestered and inactivated by IGFBPs with minimal free active fraction. Engineered IGF-1 LR3 barely binds IGFBPs, greatly elevating free active circulating concentration and delivering 2–3 times higher potency than endogenous IGF-1 with sustained long-term activity.
It directly binds IGF-1 receptors expressed on nearly all human cells and activates two core signaling cascades: PI3K/Akt/mTOR and MAPK/ERK. It simultaneously exerts five major biological effects: potent anabolism, anti-catabolism, cell proliferation & regeneration, tissue repair and metabolic regulation. It is widely applied in in vitro cell culture and preclinical animal research focusing on muscle regeneration, bone repair, nerve injury and aging mechanisms.
What is Acetic Acid 1% (Sterile Solvent)?
💥
Muscle Cell Hyperplasia
The “Holy Grail” of muscle building. Functions as a potent catalyst for actual muscle cell *splitting* (Hyperplasia), creating entirely new muscle fibers, thereby increasing the genetic upper limit of a muscle’s mass potential.
✨
20+ Hour Extended Half-Life
Thanks to its molecular stealth, IGF-1 LR3 boasts a staggering half-life of 20 to 30 hours. This provides a constant, powerful anabolic signal to the body, far surpassing the 20-minute window of endogenous IGF-1.
🛡️
IGFBP Immunity (Arg3 Modified)
Engineered with the crucial Long Arg3 modification. This renders the peptide invisible to the inhibitory IGF Binding Proteins that normally deactivate natural IGF-1 within minutes, unlocking pure, raw potency.
🔥
Nutrient Partitioning Master
Directs nutrients systemically. It dramatically increases the uptake of glucose, amino acids, and creatine into muscle cells, ensuring that caloric intake is utilized for tissue building rather than fat storage.
💾
IGF-1 Receptor Unbound Access
By bypassing binding proteins, it creates an unmatched density of unbound, active IGF-1 ligands, resulting in unprecedented activation of the systemic IGF-1 receptor (IGF-1R) pathway for total-body regeneration.
💎
Verified High Purity (>99%)
Produced via advanced SPPS technology, ensuring a ≥99.0% HPLC-verified purity level. This ultra-pure 83-amino-acid protein is ideal for sensitive cell culture and long-term metabolic studies.
How It Works: The “Hyperplasia Engine” Mechanism
- Receptor Binding & Signaling ActivationIGF-1 LR3 selectively binds transmembrane tyrosine kinase IGF-1R, triggering receptor autophosphorylation and IRS-1 recruitment to activate two major downstream cascades:
- PI3K/Akt/mTOR axis: Master regulator of protein synthesis, glucose uptake, anti-apoptosis and muscle catabolism suppression;
- MAPK/ERK axis: Governs stem cell proliferation, cell differentiation, new muscle fiber formation and angiogenesis.
- IGFBP Resistance (Core Structural Advantage)Native IGF-1 is rapidly captured and inactivated by six IGF-binding proteins; IGF-1 LR3 exhibits ~1000-fold reduced IGFBP affinity, maintaining constant free bioactivity and extended half-life, once-daily injection sustains full-day signaling.
- Dual Regulation of Muscle MetabolismmTOR accelerates ribosomal translation to boost amino acid incorporation into muscle protein; Akt inhibits FOXO transcription factors and silences catabolic genes MuRF1 & atrogin-1, delivering dual benefits of boosting anabolism while blocking breakdown.
- Satellite Cell Activation (Unique Mechanism)Muscle satellite cells are resident muscle stem cells. IGF-1 LR3 drives their proliferation and differentiation, enabling fusion into existing myofibers and even formation of entirely new muscle fibers (hyperplasia), unlike conventional peptides that only enlarge existing fibers (hypertrophy).
- Insulin-like Glucose ModulationUpregulate glucose transporters on muscle, adipose and hepatocytes to accelerate peripheral blood glucose uptake and improve insulin sensitivity; lower hypoglycemia risk compared to exogenous insulin.
Core Efficacy
1: Bone, Cartilage & Tendon Regeneration
- Stimulate osteoblast proliferation & increase bone mineral densityActivate bone-forming cells, accelerate calcium mineral deposition, assist recovery from bone fissures and fractures, and slow age-related bone loss in osteoporosis research models.
- Repair articular cartilage wearBoost chondrocyte synthesis of type Ⅱ collagen and proteoglycans, repair exercise-induced cartilage abrasion, relieve synovitis, joint effusion and movement-related joint pain.
- Strengthen tendon & ligament collagen matrixUpregulate type Ⅰ & Ⅲ collagen secretion to thicken tendon fibers, relieve tendinitis and minor ligament sprains, reduce recurrence risk of sports joint strain.
2: Systemic Tissue Repair, Wound Healing & Dermal Anti-Aging
- Accelerate all types of wound closureSpeed epithelialization of surgical incisions, abrasions, burns and chronic ulcers, stimulate granulation tissue formation, shorten healing duration and reduce hypertrophic scar formation.
- Dermal collagen regeneration & anti-agingStimulate dermal fibroblast proliferation, massively synthesize collagen and elastin to thicken dermis, fade fine lines, sagging and photoaging dullness.
- Angiogenesis to repair ischemic tissueUpregulate VEGF and FGF to drive microvascular regeneration, improve blood & oxygen supply to local tissue and repair ischemic damaged skin and soft tissue.
- Anti-apoptosis to slow tissue senescenceSustain activation of Akt anti-apoptotic signaling, slow systemic programmed cell death and delay organ & cutaneous aging progression.
🧪 What’s In The Vial
- Active Compound: IGF-1 LR3 (Long Arg3 IGF-1)
- Structure: 83-Amino-Acid Modified Polypeptide
- State: Sterile, Lyophilized Powder
- Net Contents: As selected (100mcg – 1mg)
- Purity: ≥99.0% (HPLC Verified)
👩🔬 Who Uses It
- Anti-Aging & Cellular Regeneration Scientists
- Hypertrophy & Hyperplasia Investigators
- Cellular Growth Studies (Akt/mTOR pathway)
- Satellite Cell Activation Researchers
- Metabolic Syndrome Analysts
🔗 Best Paired With
- Sterile Bacteriostatic Water (BAC)
- Calibrated Insulin Syringes (Micro-dosing)
- HGH / CJC-1295 / GHRP (For systemic IGF-1 cascade)
- Mitochondrial Support (NAD+ / SS-31 for energy synergy)
AS MENTIONED ON
Real People, Real Transformations
16 weeks
DURATION
+18 lbs
LEAN MASS
-7%
BODY FAT
“RESEARCHER NOTES: This subject struggled to gain weight for years. Upon introducing the CJC-1295 / Ipamorelin blend protocol, the results clicked. Muscle fullness improved significantly, and recovery time was cut in half.”
— Liam, age 24
12 weeks
DURATION
+14 lbs
LEAN MASS
-9%
BODY FAT
“I’d been training for years but never really saw the results. Once I started my IGF-1 LR3 and BPC-157 protocol, everything clicked. The lean tissue gains and joint recovery are unreal.”
— Marcus, age 30
12 weeks
DURATION
+10 lbs
LEAN MASS
-8%
BODY FAT
“I wanted muscle tone without ‘bulking’. Adding Ipamorelin to my regimen allowed me to train consistently. The mirror shows lean changes I couldn’t achieve with diet alone.”
— Sarah, age 29
12 weeks
DURATION
-28 lbs
LEAN MASS
-15%
BODY FAT
“RESEARCHER NOTES: Targeted a stubborn fat protocol with Tirzepatide. This subject experienced a massive reduction in visceral fat within the first 6 weeks without losing lean mass.”
— David, age 45
16 weeks
DURATION
-24 lbs
LEAN MASS
-12%
BODY FAT
“The fat just wouldn’t budge around my mid-section. Once I introduced Semaglutide into my research protocol, the weight loss was immediate, sustainable, and my cravings disappeared.”
— Emily, age 32
12 weeks
DURATION
-35 lbs
LEAN MASS
-18%
BODY FAT
“By targeting metabolic efficiency with Tesamorelin and AOD-9604, muscle tissue was preserved while stubborn visceral fat melted away. Completely different physique.”
— Daniel, age 41
8 weeks
DURATION
+45%
CLARITY
+60%
ELASTICITY
“I struggled with persistent redness and uneven texture. After adopting a GHK-Cu peptide protocol, the inflammation vanished. My skin literally glows from the inside.”
— Chloe, age 27
12 weeks
DURATION
+55%
REPAIR
+30%
YOUTHFUL
“My face looked permanently tired. Working with Epithalon and GHK-Cu was a game changer. Pores minimized, fine lines reduced, and I’m sleeping deeper too.”
— Jason, age 36
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28 Reviews
28 reviews for IG1| IGF-1LR3｜1mg*10vials| 0.1mg-1mg|>99% Purity
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Cedric Oakley –
This IG1 IGF-1LR3 is acetate-buffered sterile white lyophilized peptide powder with HPLC purity ≥99%. Unlike most peptides, its unique formulation requires sealed vial storage at 20–25°C with light & moisture protection—freezing will irreversibly damage its long insulin-like growth factor peptide chain. Stable ambient dark storage prevents hydrolysis, retaining consistent muscle cell proliferation and tissue growth activity for metabolic & muscle regeneration research over months.
Graham Z. –
I have ordered IGF-1 LR3 from many vendors, and this batch is noticeably cleaner. The lyophilized powder stays bright white right out of the vial. It dissolves easily with gentle swirling with no heavy shaking required.
Hilda A. –
The 1mg vial size fits my micro-dosing perfectly, so I never waste leftover peptide. The buffered pH keeps the protein stable after mixing. This is my regular reorder for cell repair research, and the quality never changes between shipments.
Ewan X. –
Ideal for muscle growth and anti-aging research. The acetate buffer prevents peptide breakdown after reconstitution. I only mix small batches each time, and the liquid stays clear and stable for days. Shipping was discreet and no vials arrived cracked.
4
Wesley Kade –
Two flexible dosage specifications (0.1mg, 1mg per vial) fully cover all stages of my research workflow. The standard 1mg single vial fill size is calibrated for medium-scale in-vivo muscle growth trials; I only reconstitute a single vial per testing cycle to eliminate waste of diluted IGF-1LR3 that rapidly loses biological potency once exposed to direct sunlight.
Paisley V. –
This IGF-1 LR3 works well for more than basic anti-aging studies. I also use it for muscle cell differentiation in-vitro trials, and the consistent acetate buffer pH eliminates the need to add extra neutralizing agents to my culture media mixes.
Faye Y. –
Molecular weight perfectly matches the listed value. This research-grade product has no fillers or extra impurities. As long as I avoid freezing, the peptide activity stays consistent month after month with no loss of strength.
Clayton V. –
This IGF-1 LR3 is high-quality white lyophilized powder with acetate buffer. HPLC testing verified purity above 99%. The pH stays stable between 4.0–6.0. I keep the vials between 20–25°C without freezing, and the peptide maintains full potency without degradation.
Orin U. –
The shipping packaging uses individual foam dividers for each glass vial to avoid collision damage. I’ve ordered three international bulk shipments so far, and zero vials arrived cracked, leaking or contaminated during long transit times.
Freya L. –
This long-chain IGF protein is indispensable for my cellular repair and anti-aging lab research. The built-in acetate buffer holds pH between 4.0–6.0, which effectively slows protein unfolding once reconstituted with solvent. Every glass vial arrived fully sealed and undamaged after cross-border shipping.
Elias K. –
All vials inside the 10-unit bulk pack have consistent fine lyophilized powder with zero clumping right out of the box. It dissolves rapidly into fully transparent liquid without any floating protein aggregates. The tight gold crimp cap creates a moisture-proof seal, so humidity won’t ruin the powder after repeated punctures for sampling.
Seth Rowe –
IGF-1LR3 acts as my core research peptide for muscle cell differentiation, insulin sensitivity and skeletal muscle hypertrophy pathway studies. The integrated acetate buffer locks pH steadily between 4.0–6.0 to slow peptide denaturation post-reconstitution, and mixed working peptide solution stays transparent for multiple refrigerated testing cycles. All glass vials arrived fully intact with zero breakage during cross-border international lab shipping.
Daisy J. –
This IGF-1 LR3 is white acetate-buffered lyophilized protein powder with HPLC purity over 99%. Unlike other long-chain peptides that need frozen storage, this variant only requires stable 20–25°C ambient storage and must never be frozen to avoid irreversible protein denaturation. Stored in a dark cabinet, the powder stays uniform white for weeks without discoloration.
Briar Maeve –
This 10-vial bulk pack includes a steep limited-time promotional markdown that drastically cuts my monthly lab raw material procurement overhead. Vial-to-vial powder texture, peptide concentration and HPLC purity show zero measurable deviation, making all my muscle regeneration experimental data highly repeatable across separate test batches.
Ruth Maeve –
Each vial inside the standard 1mg×10 bulk kit holds ultra-fine free-flowing white lyophilized powder that dissolves fully into sediment-free crystal clear liquid after slow gentle swirling. The airtight gold aluminum flip cap creates a full humidity barrier, so powder never clumps even after repeated syringe punctures to draw tiny partial aliquots for myoblast cell culture testing.
Rhea X. –
Stable ≥99% HPLC purity, convenient room-temperature storage rules, two flexible dosage sizes and steady cross-batch consistency make this IG1 my exclusive IGF-1 LR3 supply. I reorder monthly for my long-term tissue regeneration research with zero quality complaints across all shipments.
Quentin W. –
The lyophilization process creates ultra-fine uniform powder without large hard chunks inside vials. If I only need a tiny micro-dose for preliminary screening, I can extract small amounts without having to fully reconstitute the whole vial and waste protein.
Una Quinton –
The listed CAS registry number, molecular formula and massive 9117.50 Da molecular weight align perfectly with authoritative peer-reviewed biochemical reference datasheets. This lab-grade IG1 IGF-1LR3 contains no inert bulking fillers or fragmented peptide fragments, and consistent 20–25°C dark storage blocks photo-oxidation that degrades its growth-factor active peptide structure.
Violet Rhea –
I ran blinded parallel myogenesis cell trials with IGF-1LR3 sourced from six different manufacturers, and this acetate co-lyophilized IG1 variant delivers unmatched solubility with barely any powder residue sticking to inner glass vial walls. Slow circular swirling achieves full dissolution; harsh vigorous shaking fractures the large peptide backbone and invalidates quantitative muscle proliferation assay readouts.
Dottie W. –
Potency is uniform across all 10 vials in this pack. The powder dissolves fully into a clear solution with zero sediment. The airtight vials keep out moisture well, so there is no clumping even with long-term storage at room temperature.
Linden R. –
The optimized acetate buffer formula drastically reduces protein residue stuck to vial glass walls after dissolution. I recover nearly all of the lyophilized IGF powder from each vial, which removes major dosing inaccuracies in my quantitative cell signaling research.
Kinsley Q. –
Direct sunlight is the biggest enemy of this IGF powder. I keep all unopened vials stored inside an opaque storage cabinet, and after one month of storage, the powder remains pure white with no yellowing from photo-oxidation. Reconstituted solution stays clear for multiple refrigerated days without precipitation.
Jasper P. –
This 10-vial bulk bundle has a limited-time promotional discount that greatly cuts my monthly lab raw material expenses. Vial-to-vial powder density, texture and purity show no measurable differences, making my cell culture experimental data highly repeatable batch after batch.
Galen M. –
The CAS number, molecular formula and 9117.50 Da molecular weight completely match the official specification sheet. No unknown impurities, protein fragments or inert bulking agents are detected during HPLC testing. Room-temperature storage eliminates risks of freeze-thaw damage to the fragile polypeptide chain.
Niamh T. –
I run third-party HPLC spot checks on random vials from each shipment, and every sample consistently hits ≥99% purity with no extra impurity peaks on chromatograms. The lab audit-friendly purity documentation is perfect for regulated research environments.
Ignis O. –
They supply two convenient specifications: 0.1mg and 1mg per vial. The 1mg vial is ideal for my medium-scale proliferation trials, letting me reconstitute just one vial per experiment to prevent wasting diluted IGF solution that quickly loses biological activity over time.
Hilda N. –
I’ve tested IGF-1 LR3 products from many suppliers for cell culture comparison, and this acetate-stabilized lyophilized version has far less glass-wall adhesion after mixing. Gentle slow swirling is enough to fully solubilize the powder; harsh shaking will break the long protein structure and ruin assay results.
Merrick S. –
I accidentally froze a spare vial during a fridge malfunction once, and the powder turned lumpy and failed solubility tests afterward. This really drives home how critical it is to follow the 20–25°C non-freezing storage guidance for this IGF-1 LR3 product.